Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system (CNS). MS is thought to be T-cell-mediated, with prior research predominantly
focusing on CD4+ T-cells. There is a high prevalence of CNS-specific CD8+ T-cell
responses in MS patients and healthy subjects. However, the role of neuroantigen-specific
CD8+ T-cells in MS is poorly understood, with the prevalent notion that these may represent
pathogenic T-cells. We show here that healthy subjects and MS patients demonstrate similar …